Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome

Barbara L. Cool, Bradley A. Zinker, William J. Chiou, +13

Cell Metabolism

Metabolic SyndromeSignal TransductionBiochemistryMedicineNatural Sciences +10

Regiocontrol in an Intramolecular Schmidt Reaction:  Total Synthesis of (+)-Aspidospermidine

Rajesh Iyengar, Klaas Schildknegt, Jeffrey Aubé

Organic Letters

Revisiting a Classic Approach to the <i>Aspidosperma</i> Alkaloids:  An Intramolecular Schmidt Reaction Mediated Synthesis of (+)-Aspidospermidine

Rajesh Iyengar, Klaas Schildknegt, Martha Morton, +1

The Journal of Organic Chemistry

Stereoselective syntheses of substituted pterocarpans with anti-HIV activity, and 5-aza-/5-thia-pterocarpan and 2-aryl-2,3-dihydrobenzofuran analogues

Thomas A. Engler, Kenneth O. LaTessa, Rajesh Iyengar, +2

Bioorganic & Medicinal Chemistry

Medicinal ChemistryBioorganic ChemistryNatural SciencesMedicineStereoselective Syntheses +7

Asymmetric Reactions of 2-Methoxy-1,4-benzoquinones with Styrenyl Systems:  Enantioselective Syntheses of 8-Aryl-3-methoxybicyclo[4.2.0]oct-3-en-2,5-diones, 7-Aryl-3-hydroxybicyclo[3.2.1]oct-3-en-2,8-diones, 2-Aryl-6-methoxy-2,3-dihydrobenzofuran-5-ols, and Pterocarpans

Thomas A. Engler, Michael A. Letavic, Rajesh Iyengar, +2

The Journal of Organic Chemistry

EngineeringOrganic ChemistryChemistryHeterocycle ChemistryStyrenyl Systems +14

Optimization of Chromone-2-carboxamide Melanin Concentrating Hormone Receptor 1 Antagonists:  Assessment of Potency, Efficacy, and Cardiovascular Safety

J.A. Lynch, Jennifer C. Freeman, Andrew S. Judd, +29

Journal of Medicinal Chemistry

Metabolic SyndromeMedicinal ChemistryDistinct SeriesPharmacological StudyMedicine +12

Discovery and Characterization of Aminopiperidinecoumarin Melanin Concentrating Hormone Receptor 1 Antagonists

Philip R. Kym, Rajesh Iyengar, Andrew J. Souers, +36

Journal of Medicinal Chemistry

Cardiovascular PharmacologyPharmacotherapyMetabolic SyndromePharmacological StudyMchr1 Antagonists +15

Lack of efficacy of melanin-concentrating hormone-1 receptor antagonists in models of depression and anxiety

Ana M. Basso, Natalie A. Bratcher, Kelly B. Gallagher, +14

European Journal of Pharmacology

Stress HormonePsychiatryMood SymptomMedicinePsychotropic Medication +9

Screening for Cardiovascular Safety:  A Structure−Activity Approach for Guiding Lead Selection of Melanin Concentrating Hormone Receptor 1 Antagonists

Philip R. Kym, Andrew J. Souers, Thomas Campbell, +23

Journal of Medicinal Chemistry

Lewis Acid-Directed Reactions of Quinones with Styrenyl Systems:  The Case of 2-Methoxy-3-methyl-1,4-benzoquinone

Thomas A. Engler, Rajesh Iyengar

The Journal of Organic Chemistry

Styrenyl SystemsChemical EngineeringEngineeringHeterocyclicRegioisomeric Rel- +8