Chris D. Edwards

Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity

Richard Angell, Paul Bamborough, Jacky B. Buckton et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 72 citations · Full text

Medicinal Chemistry, Vivo Activity, Chemoprevention Strategy +11

Discovery of 6-Amino-2-{[(1<i>S</i>)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8<i>H</i>-purin-8-one (GSK2245035), a Highly Potent and Selective Intranasal Toll-Like Receptor 7 Agonist for the Treatment of Asthma

Keith Biggadike, Mahbub Ahmed, D.I. Ball et al. · Journal of Medicinal Chemistry · 2016 · 40 citations

Asthma, Inflammatory Lung Disease, Lung Inflammation +29

Selectivity in the impact of P-glycoprotein upon pulmonary absorption of airway-dosed substrates: A study in ex vivo lung models using chemical inhibition and genetic knockout

Ghaith Aljayyoussi, Daniel F. Price, Danielle Francombe et al. · Journal of Pharmaceutical Sciences · 2013 · 32 citations · Full text

Asthma, Lung Deposition, Biochemistry +8

Development of a Novel Quantitative Structure-Activity Relationship Model to Accurately Predict Pulmonary Absorption and Replace Routine Use of the Isolated Perfused Respiring Rat Lung Model

Chris D. Edwards, Chris Luscombe, Peter Eddershaw et al. · Pharmaceutical Research · 2016 · 31 citations · Full text

A phase I study of the trinuclear platinum compound, BBR�3464, in combination with protracted venous infusional 5-fluorouracil in patients with advanced cancer

Charlie Gourley, James T. Cassidy, Chris D. Edwards et al. · Cancer Chemotherapy and Pharmacology · 2004 · 28 citations

Advanced Cancer, Oncology, Medicine +8