Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development

Paulina Kucharzewska, Helena C. Christianson, Johanna E. Welch, +7

Proceedings of the National Academy of Sciences

Biological MicroenvironmentsExtracellular MicrovesiclesCancer BiologyGliomaCellular Physiology +15

Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis

Rajesh R. Rao, Jonathan Z. Long, James P. White, +13

Cell

ObesityMetabolic SyndromeEnergy HomeostasisBody CompositionEndocrine Mechanism +9

Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch

Paul Cohen, Julia D. Levy, Yingying Zhang, +19

Cell

ObesityMetabolic SyndromeBody CompositionMetabolic DisorderAdipose Tissue +11

Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity

Helena C. Christianson, Katrin J. Svensson, Toin H. Van Kuppevelt, +2

Proceedings of the National Academy of Sciences

Molecular BiologyExtracellular MicrovesiclesTumor BiologyEndocytic PathwayCancer Cell Biology +16

Exosome Uptake Depends on ERK1/2-Heat Shock Protein 27 Signaling and Lipid Raft-mediated Endocytosis Negatively Regulated by Caveolin-1

Katrin J. Svensson, Helena C. Christianson, Anders Wittrup, +5

Journal of Biological Chemistry

A Smooth Muscle-Like Origin for Beige Adipocytes

Jonathan Z. Long, Katrin J. Svensson, Linus Tsai, +10

Cell Metabolism

Molecular PhysiologyDevelopmental BiologyAdipose TissuePhysiologyTissue Physiology +6

Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2–mediated heparin-binding EGF signaling in endothelial cells

Katrin J. Svensson, Paulina Kucharzewska, Helena C. Christianson, +7

Proceedings of the National Academy of Sciences

The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria

Jonathan Z. Long, Katrin J. Svensson, Leslie A. Bateman, +12

Cell

Mitochondrial FunctionBiochemistryNatural SciencesMitochondrial DynamicLipid Peroxidation +7

A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function

Katrin J. Svensson, Jonathan Z. Long, Mark P. Jedrychowski, +10

Cell Metabolism

Signal TransductionLipid SynthesisBiochemistryMetabolic FunctionPhysiology +12

Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis

Zewen Jiang, Meng Zhao, Laëtitia Voilquin, +17

Cell Metabolism

ObesityMetabolic SyndromeGlucose ToleranceMetabolic DisorderMedicine +9