Exosome Uptake Depends on ERK1/2-Heat Shock Protein 27 Signaling and Lipid Raft-mediated Endocytosis Negatively Regulated by Caveolin-1

Katrin J. Svensson, Helena C. Christianson, Anders Wittrup, +5

Journal of Biological Chemistry

Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown

Anders Wittrup, Angela Ai, Xing Liu, +6

Nature Biotechnology

Lipid PreparationProteinlipid InteractionSystems BiologyNatural SciencesLipid-formulated Sirna Release +3

The Human Antimicrobial Peptide LL-37 Transfers Extracellular DNA Plasmid to the Nuclear Compartment of Mammalian Cells via Lipid Rafts and Proteoglycan-dependent Endocytosis

Staffan Sandgren, Anders Wittrup, Fang Cheng, +4

Journal of Biological Chemistry

Imaging small molecule-induced endosomal escape of siRNA

Hampus Du Rietz, Hampus Hedlund, Sten Wilhelmson, +2

Nature Communications

N-terminal peptides from unprocessed prion proteins enter cells by macropinocytosis

Mazin Magzoub, Staffan Sandgren, Pontus Lundberg, +7

Biochemical and Biophysical Research Communications

Protein SecretionProtein FunctionNatural SciencesMolecular BiologyPrion Disease +3

Gene Knockdown by EpCAM Aptamer–siRNA Chimeras Suppresses Epithelial Breast Cancers and Their Tumor-Initiating Cells

Adi Gilboa-Geffen, Péter Hamar, Minh T. N. Le, +5

Molecular Cancer Therapeutics

Magnetic nanoparticle-based isolation of endocytic vesicles reveals a role of the heat shock protein GRP75 in macromolecular delivery

Anders Wittrup, Sihe Zhang, Katrin J. Svensson, +4

Proceedings of the National Academy of Sciences

Cancer Cells Can Exhibit a Sparing FLASH Effect at Low Doses Under Normoxic In Vitro-Conditions

Gabriel Adrian, Elise Konradsson, Sarah Beyer, +6

Frontiers in Oncology

ScFv Antibody-induced Translocation of Cell-surface Heparan Sulfate Proteoglycan to Endocytic Vesicles

Anders Wittrup, Sihe Zhang, Gerdy B. ten Dam, +6

Journal of Biological Chemistry

ImmunologyViral Structural ProteinImmunotherapyEndocytic PathwayAntibody Engineering +15

Identification of Proteins Released by Mammalian Cells That Mediate DNA Internalization through Proteoglycan-dependent Macropinocytosis

Anders Wittrup, Staffan Sandgren, Johanna Lilja, +4

Journal of Biological Chemistry

Dna UptakeImmunologyMolecular BiologyCytoskeletonCellular Physiology +14