Kevin Meldrum

Biocatalytic reductive amination from discovery to commercial manufacturing applied to abrocitinib JAK1 inhibitor

Rajesh Kumar, Michael J. Karmilowicz, Dylan Burke et al. · Nature Catalysis · 2021 · 129 citations

Medicinal Chemistry, Engineering, Commercial Manufacturing +10

Synthesis of trihydroxylated pyrrolizidines and indolizidines using cycloaddition reactions of functionalized cyclic nitrones, and the synthesis of (+)- and (−)-lentiginosine

A. E. MCCAIG, Kevin Meldrum, R. H. WIGHTMAN · Tetrahedron · 1998 · 88 citations

Natural Product Synthesis, Organic Chemistry, Trihydroxylated Pyrrolizidines +5

Synthesis of Hydroxylated Pyrrolizidines Related to Alexine using Cycloaddition Reactions of Functionalized Cyclic Nitrones

Adrian Hall, Kevin Meldrum, Patrick Therond et al. · Synlett · 2004 · 52 citations

Natural Product Synthesis, Engineering, Hydroxylated Pyrrolizidines 6 +12

The Development of a Practical Multikilogram Synthesis of the Chiral β-Amino Acid Imagabalin Hydrochloride (PD-0332334) via Asymmetric Hydrogenation

Melissa Birch, Stephen Challenger, Jean-Philippe Crochard et al. · Organic Process Research & Development · 2011 · 26 citations

Engineering, Practical Multikilogram Synthesis, Biochemistry +12

A Simplified Process for the Manufacture of Imagabalin Hydrochloride (PD-0332334), an α2δ-Ligand for the Treatment of Generalised Anxiety Disorder

Melissa Birch, Stephen Challenger, Jean-Philippe Crochard et al. · Organic Process Research & Development · 2011 · 14 citations

Simplified Process, Engineering, Psychotropic Medication +24