Concepedia

Patrick C. Fraering

PC

39

Publications

2.6K

Citations

29

H-Index

2001

Active since

Affiliations

École Polytechnique Fédérale de Lausanne(Current)

Harvard University

Brigham and Women's Hospital

University of Fribourg

Shanghai Jiao Tong University

Patrick C. Fraering is an author at École Polytechnique Fédérale de Lausanne specializing in medicine, biochemistry, and natural sciences.

Top concepts

MedicineBiochemistryNatural SciencesMolecular BiologyAlzheimer's DiseaseCellular BiochemistryNeurodegenerative DiseasesProteomicsNeuroscienceProtective Mechanisms

Publications per year

2001–2019

39

Publications

39

Substrate-targeting γ-secretase modulators

Thomas Kukar, Thomas B. Ladd, Maralyssa Bann et al. · Nature · 2008 · 275 citations · Full text

Protein Secretion, Signal Transduction, Protein Expression +5

Purification and Characterization of the Human γ-Secretase Complex

Patrick C. Fraering, Wenjuan Ye, Jean‐Marc Strub et al. · Biochemistry · 2004 · 227 citations · Full text

Assembly of the γ-Secretase Complex Involves Early Formation of an Intermediate Subcomplex of Aph-1 and Nicastrin

Matthew J. LaVoie, Patrick C. Fraering, Beth L. Ostaszewski et al. · Journal of Biological Chemistry · 2003 · 207 citations · Full text

Electron microscopic structure of purified, active γ-secretase reveals an aqueous intramembrane chamber and two pores

Vlado K. Lazarov, Patrick C. Fraering, Wenjuan Ye et al. · Proceedings of the National Academy of Sciences · 2006 · 160 citations · Full text

Protein Secretion, Electron Microscopic Structure, Protein Assembly +19

Detergent-Dependent Dissociation of Active γ-Secretase Reveals an Interaction between Pen-2 and PS1-NTF and Offers a Model for Subunit Organization within the Complex

Patrick C. Fraering, Matthew J. LaVoie, Wenjuan Ye et al. · Biochemistry · 2003 · 126 citations · Full text

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