Kimberly Lapham

Optimized Assays for Human UDP-Glucuronosyltransferase (UGT) Activities: Altered Alamethicin Concentration and Utility to Screen for UGT Inhibitors

Robert L. Walsky, Jonathan Bauman, Karine Bourcier et al. · Drug Metabolism and Disposition · 2012 · 149 citations

Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical Candidate

Samit K. Bhattacharya, Kim Andrews, Ramsay E. Beveridge et al. · ACS Medicinal Chemistry Letters · 2014 · 67 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Biochemistry +10

Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality

Christopher R. Butler, Kevin Ogilvie, Luis Martinez-Alsina et al. · Journal of Medicinal Chemistry · 2016 · 42 citations · Full text

Drug Target, Glycobiology, Similar Potency +23

Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation

Brian T. O’Neill, Elizabeth M. Beck, Christopher R. Butler et al. · Journal of Medicinal Chemistry · 2018 · 41 citations · Full text

Enzyme 1, Inhibitor Lacking Hypopigmentation, Molecular Pharmacology +20

Identification of potent, selective, CNS-targeted inverse agonists of the ghrelin receptor

Kim F. McClure, Margaret Jackson, Kimberly O. Cameron et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 27 citations · Full text

Signal Transduction, Cns-targeted Inverse Agonists, Functional Selectivity +10