Sravanthi Cheeti

Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)

John A. Flygare, Maureen H. Beresini, Nageshwar Budha et al. · Journal of Medicinal Chemistry · 2012 · 247 citations · Full text

Apoptosis, Cell Death, Clinical Candidate +20

Pharmacokinetics of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Locally Advanced or Metastatic Solid Tumors: the Role of Alpha-1-Acid Glycoprotein Binding

Richard Graham, Bert L. Lum, Sravanthi Cheeti et al. · Clinical Cancer Research · 2011 · 116 citations · Full text

A physiologically based pharmacokinetic (PBPK) approach to evaluate pharmacokinetics in patients with cancer

Sravanthi Cheeti, Nageshwar Budha, Sharmila Rajan et al. · Biopharmaceutics & Drug Disposition · 2012 · 103 citations

Pharmacokinetic Dose-Scheduling Study of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Locally Advanced or Metastatic Solid Tumors

Patricia LoRusso, Antonio Jimeno, Grace K. Dy et al. · Clinical Cancer Research · 2011 · 89 citations · Full text

Determination of GDC-0449, a small-molecule inhibitor of the Hedgehog signaling pathway, in human plasma by solid phase extraction-liquid chromatographic-tandem mass spectrometry

Xiao Ding, Bilin Chou, Richard Graham et al. · Journal of Chromatography B · 2010 · 40 citations

Medicine, Mass Spectrometry, Human Plasma +4