Anthea Hardcastle

Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response

Maruf M. U. Ali, Tina Bagratuni, Emma L. Davenport et al. · The EMBO Journal · 2011 · 246 citations · Full text

Protein Function, Signal Transduction, Biochemistry +9

A Phase I Study of the Heat Shock Protein 90 Inhibitor Alvespimycin (17-DMAG) Given Intravenously to Patients with Advanced Solid Tumors

Simon Pacey, Richard H. Wilson, Mike Walton et al. · Clinical Cancer Research · 2011 · 189 citations · Full text

Inhibition of the heat shock protein 90 molecular chaperone <i>in vitro</i> and <i>in vivo</i> by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues

Swee Y. Sharp, Chrisostomos Prodromou, Kathy Boxall et al. · Molecular Cancer Therapeutics · 2007 · 142 citations

Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines

A.L. Jackman, Rosemary Kimbell, Melody Brown et al. · British Journal of Cancer · 1995 · 102 citations · Full text

Natural Sciences, Molecular Biology, Resistance Mutation (Virology) +5

Lack of correlation between thymidylate synthase levels in primary colorectal tumours and subsequent response to chemotherapy

David Cunningham, Geoffrey Morgan, Sarah A. Clinton et al. · British Journal of Cancer · 1997 · 100 citations · Full text

Subsequent Response, Tumor Biology, Oncogenic Agent +9