Jeng Yie Chan

Cytokine-Induced β-Cell Death Is Independent of Endoplasmic Reticulum Stress Signaling

Mia C. Åkerfeldt, Jennifer E. Howes, Jeng Yie Chan et al. · Diabetes · 2008 · 133 citations · Full text

Failure of the Adaptive Unfolded Protein Response in Islets of Obese Mice Is Linked With Abnormalities in β-Cell Gene Expression and Progression to Diabetes

Jeng Yie Chan, Jude Luzuriaga, Mohammed Bensellam et al. · Diabetes · 2012 · 121 citations · Full text

Metabolic Remodeling, Insulin Signaling, Oxidative Stress +18

The balance between adaptive and apoptotic unfolded protein responses regulates β-cell death under ER stress conditions through XBP1, CHOP and JNK

Jeng Yie Chan, Jude Luzuriaga, Emma Maxwell et al. · Molecular and Cellular Endocrinology · 2015 · 119 citations

Signal Transduction, Cell Regulation, Medicine +10

A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes

Heshan Peiris, Michael D. Duffield, João Fadista et al. · PLoS Genetics · 2016 · 95 citations · Full text

Metabolic Disorder, Mitochondrial Dysfunction, Genetics +19

Hypoxia reduces ER-to-Golgi protein trafficking and increases cell death by inhibiting the adaptive unfolded protein response in mouse beta cells

Mohammed Bensellam, Emma Maxwell, Jeng Yie Chan et al. · Diabetologia · 2016 · 77 citations · Full text

Reductive Stress, Mitophagy, Signal Transduction +13