Jude Luzuriaga

Failure of the Adaptive Unfolded Protein Response in Islets of Obese Mice Is Linked With Abnormalities in β-Cell Gene Expression and Progression to Diabetes

Jeng Yie Chan, Jude Luzuriaga, Mohammed Bensellam et al. · Diabetes · 2012 · 121 citations · Full text

Metabolic Remodeling, Insulin Signaling, Oxidative Stress +18

The balance between adaptive and apoptotic unfolded protein responses regulates β-cell death under ER stress conditions through XBP1, CHOP and JNK

Jeng Yie Chan, Jude Luzuriaga, Emma Maxwell et al. · Molecular and Cellular Endocrinology · 2015 · 119 citations

Signal Transduction, Cell Regulation, Medicine +10

Hypoxia reduces ER-to-Golgi protein trafficking and increases cell death by inhibiting the adaptive unfolded protein response in mouse beta cells

Mohammed Bensellam, Emma Maxwell, Jeng Yie Chan et al. · Diabetologia · 2016 · 77 citations · Full text

Reductive Stress, Mitophagy, Signal Transduction +13

Inhibitor of differentiation proteins protect against oxidative stress by regulating the antioxidant–mitochondrial response in mouse beta cells

Mohammed Bensellam, Magdalene K. Montgomery, Jude Luzuriaga et al. · Diabetologia · 2015 · 62 citations · Full text

Redox Signaling, Mitochondrial Function, Biochemistry +9

Pharmacological reduction of NEFA restores the efficacy of incretin-based therapies through GLP-1 receptor signalling in the beta cell in mouse models of diabetes

Zhanfang Kang, Yi Deng, Yinggang Zhou et al. · Diabetologia · 2012 · 55 citations · Full text