Concepedia

The balance between adaptive and apoptotic unfolded protein responses regulates β-cell death under ER stress conditions through XBP1, CHOP and JNK

Jeng Yie Chan, Jude Luzuriaga, Emma Maxwell, Phillip K. West, Mohammed Bensellam, D. Ross Laybutt

Molecular and Cellular Endocrinology · 2015 · 121 citations · 42 references

DOI

Concepts

References

42

Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1

Fumihiko Urano, Xiao-Zhong Wang, Anne Bertolotti et al. · Science · 2000 · 3K citations

, , +16

Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes

Seiichi Oyadomari, Akio Koizumi, Tomomi Gotoh et al. · Journal of Clinical Investigation · 2002 · 866 citations · Full text

, , +17

Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

D. Ross Laybutt, Amanda M. Preston, M. C. Åkerfeldt et al. · Diabetologia · 2007 · 822 citations · Full text

, , +16

IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates

Dan Han, Alana G. Lerner, Lieselotte Vande Walle et al. · Cell · 2009 · 804 citations · Full text

, , +6

Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes

Seiichi Oyadomari, Akio Koizumi, Tomomi Gotoh et al. · Journal of Clinical Investigation · 2002 · 748 citations

, , +17