Cytokine-Induced β-Cell Death Is Independent of Endoplasmic Reticulum Stress Signaling - Concepedia

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Publication | Open Access

Cytokine-Induced β-Cell Death Is Independent of Endoplasmic Reticulum Stress Signaling

DOI Full Paper Access

133

Citations

42

References

2008

Year

Mia C. Åkerfeldt, Jennifer E. Howes, Jeng Yie Chan, Veronica Stevens, Nacer Boubenna, Helen M. McGuire, Trevor J. Biden, D. Ross Laybutt

Abstract

While both cytokines and palmitate can induce ER stress, our results suggest that, in contrast to lipoapoptosis, the PERK-ATF4-CHOP ER stress-signaling pathway is not necessary for cytokine-induced beta-cell death.

References

	Year	Citations
β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes Alexandra E. Butler, Juliette Janson, Susan Bonner‐Weir, Diabetes	2003	4K
Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes Umut Özcan, Qiong Cao, Erkan Yılmaz, Science Metabolic DisorderEr StressInsulin ReceptorMetabolic RemodelingInsulin Signaling	2004	3.8K
Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells Heather P. Harding, Isabel Novoa, Yuhong Zhang, Molecular Cell Transcriptional RegulationDevelopmental BiologyCell RegulationMedicineGene Regulation	2000	3.2K
Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1 Fumihiko Urano, Xiao-Zhong Wang, Anne Bertolotti, Science	2000	2.9K
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response Anne Bertolotti, Yuhong Zhang, Linda M. Hendershot, Nature Cell Biology Unfolded-protein ResponseReductive StressEr Stress TransducersDynamic InteractionSignal Transduction	2000	2.8K
Chemical Chaperones Reduce ER Stress and Restore Glucose Homeostasis in a Mouse Model of Type 2 Diabetes Umut Özcan, Erkan Yılmaz, Lale Özcan, Science Lipid PeroxidationHomeostatic MechanismEr StressMetabolic RemodelingInsulin Signaling	2006	2.4K
Gadd153 Sensitizes Cells to Endoplasmic Reticulum Stress by Down-Regulating Bcl2 and Perturbing the Cellular Redox State Karen D. McCullough, Jennifer L. Martindale, Lars‐Oliver Klotz, Molecular and Cellular Biology	2001	1.9K
Translational Control Is Required for the Unfolded Protein Response and In Vivo Glucose Homeostasis Donalyn Scheuner, Benbo Song, Edward L. McEwen, Molecular Cell Signal TransductionProtein FoldingDiabetesPhysiologyUnfolded Protein Response	2001	1.3K
Diabetes Mellitus and Exocrine Pancreatic Dysfunction in Perk−/− Mice Reveals a Role for Translational Control in Secretory Cell Survival Heather P. Harding, Huiqing Zeng, Yuhong Zhang, Molecular Cell Signal TransductionPhysiologyDiabetesPerk−/− MiceDiabetes Complications	2001	1.2K
A mitochondrial specific stress response in mammalian cells Quan Zhao The EMBO Journal Mitochondrial BiogenesisMitochondrial FunctionMedicinePhysiologyCellular Stress Response	2002	999

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