Isaac B. Hilton

Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers

Isaac B. Hilton, Anthony D’Ippolito, Christopher M. Vockley et al. · Nature Biotechnology · 2015 · 1.8K citations · Full text

Natural Sciences, Genetics, Epigenome Editing +10

CRISPR–Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome

Tyler S. Klann, Joshua B. Black, Malathi Chellappan et al. · Nature Biotechnology · 2017 · 450 citations · Full text

Functional Regulatory Elements, Transcriptional Regulation, Enables High-throughput Screening +13

Multiplex CRISPR/Cas9-based genome engineering from a single lentiviral vector

Ami M. Kabadi, David G. Ousterout, Isaac B. Hilton et al. · Nucleic Acids Research · 2014 · 378 citations · Full text

Genetics, Multiplex Gene, Molecular Biology +17

Transgenic mice for in vivo epigenome editing with CRISPR-based systems

Matthew Gemberling, Keith Siklenka, Erica Rodriguez et al. · Nature Methods · 2021 · 122 citations · Full text

Knockout Mouse, Off-target Effect, Developmental Biology +13

Single C-to-T substitution using engineered APOBEC3G-nCas9 base editors with minimum genome- and transcriptome-wide off-target effects

Sangsin Lee, Ning Ding, Yidi Sun et al. · Science Advances · 2020 · 80 citations · Full text