Paul D. Lyne

Accurate Prediction of the Relative Potencies of Members of a Series of Kinase Inhibitors Using Molecular Docking and MM-GBSA Scoring

Paul D. Lyne, Michelle L. Lamb, Jamal Saeh · Journal of Medicinal Chemistry · 2006 · 677 citations · Full text

Drug Target, Hit Identification, Relative Potencies +16

STAT3 antisense oligonucleotide AZD9150 in a subset of patients with heavily pretreated lymphoma: results of a phase 1b trial

Matthew J. Reilley, Patricia McCoon, Carl Cook et al. · Journal for ImmunoTherapy of Cancer · 2018 · 275 citations · Full text

AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia

Erika Krasnickas Keeton, Kristen McEachern, Keith Dillman et al. · Blood · 2013 · 240 citations

On Evaluating Molecular-Docking Methods for Pose Prediction and Enrichment Factors

Hongming Chen, Paul D. Lyne, Fabrizio Giordanetto et al. · Journal of Chemical Information and Modeling · 2005 · 227 citations

Hit Identification, Molecular Biology, Screening Library +20

Targeting KRAS-dependent tumors with AZD4785, a high-affinity therapeutic antisense oligonucleotide inhibitor of KRAS

Sarah J. Ross, Alexey S. Revenko, Lyndsey Hanson et al. · Science Translational Medicine · 2017 · 175 citations