Antihypertensive Effect of a γ-Aminobutyric Acid Rich Tomato Cultivar ‘DG03-9’ in Spontaneously Hypertensive Rats

Mineka Yoshimura, Tohru Toyoshi, Atsushi Sano, +8

Journal of Agricultural and Food Chemistry

Metformin Reduces Body Weight Gain and Improves Glucose Intolerance in High-Fat Diet-Fed C57BL/6J Mice

Yukari Matsui, Yasushi Hirasawa, Takahiro Sugiura, +3

Biological and Pharmaceutical Bulletin

NutritionMetabolic DisorderFood IntakeInsulin SignalingGastrointestinal Peptide Hormone +18

Effect of ipragliflozin, an SGLT2 inhibitor, on progression of diabetic microvascular complications in spontaneously diabetic Torii fatty rats

Shoji Takakura, Tohru Toyoshi, Yuka Hayashizaki, +1

Life Sciences

InflammationMetabolic SyndromeDiabetes ManagementSglt2 InhibitorMedicine +10

QT PRODACT: Usability of Miniature Pigs in Safety Pharmacology Studies: Assessment for Drug-Induced QT Interval Prolongation

Mayumi Kano, Tohru Toyoshi, Sakae Iwasaki, +3

Journal of Pharmacological Sciences

Effect of Enzymatically Modified Isoquercitrin in Spontaneously Hypertensive Rats

Kazuhiro Emura, Atsushi Yokomizo, Tohru Toyoshi, +1

Journal of Nutritional Science and Vitaminology

Pharmacological and pharmacokinetic study of olmesartan medoxomil in animal diabetic retinopathy models

Hiroaki Nakamura, Tatsuya Inoue, Naohisa Arakawa, +6

European Journal of Pharmacology

Ocular DiseaseOphthalmologyExperimental OphthalmologyMedicineDiabetes +5

An antimicrotubule agent, TZT-1027, does not induce neuropathologic alterations which are detected after administration of vincristine or paclitaxel in animal models

Tetsuo Ogawa, Yuuichi Mimura, Koichi Isowa, +7

Toxicology Letters

MedicineImmunologyPathologyAnimal ModelsNeuropathologic Alterations +7

Multi-dimensional analysis of behavior in mice treated with the delta opioid agonists DADL (d-Ala2-d-Leu5-enkephalin) and DPLPE (d-Pen2-l-Pen5-enkephalin)

Mayu Ukai, Tohru Toyoshi, Tsutomu Kameyama

Neuropharmacology

Behavioral NeuroscienceAddictionMedicineBehavioral PharmacologyMulti-dimensional Analysis +8

DAGO ([d-Ala2,N-Me-Phe4,Gly-ol]enkephalin) specifically reverses apomorphine-induced increase in rearing and grooming behaviors in the mouse

Makoto Ukai, Tohru Toyoshi, Tsutomu Kameyama

Brain Research

Knockout MouseMolecular NeuroscienceSignal TransductionMolecular PhysiologyBehavioral Neuroscience +9

Pioglitazone Improves Obesity Type Diabetic Nephropathy: Relation to the Mitigation of Renal Oxidative Reaction

Yasushi Hirasawa, Yukari Matsui, Kazusuke Yamane, +7

EXPERIMENTAL ANIMALS

Renal Oxidative ReactionInsulin SignalingOxidative StressMetabolic SyndromeRenal Function +15