Michael P. Burns

Biocatalytic reductive amination from discovery to commercial manufacturing applied to abrocitinib JAK1 inhibitor

Rajesh Kumar, Michael J. Karmilowicz, Dylan Burke et al. · Nature Catalysis · 2021 · 129 citations

Medicinal Chemistry, Engineering, Commercial Manufacturing +10

Flow-conditioned HUVECs support clustered leukocyte adhesion by coexpressing ICAM-1 and E-selectin

Michael P. Burns, Natacha DePaola · American Journal of Physiology-Heart and Circulatory Physiology · 2004 · 57 citations

Cell Adhesion, Immunology, Blood Cell +20

A Chemoenzymatic Route to Chiral Intermediates Used in the Multikilogram Synthesis of a Gamma Secretase Inhibitor

Michael P. Burns, Carlos A. Martinez, Brian C. Vanderplas et al. · Organic Process Research & Development · 2017 · 39 citations · Full text

Medicinal Chemistry, Bioorganic Chemistry, Chiral Intermediates +15

Application of Biocatalytic Reductive Amination for the Synthesis of a Key Intermediate to a CDK 2/4/6 Inhibitor

Shengquan Duan, Daniel W. Widlicka, Michael P. Burns et al. · Organic Process Research & Development · 2021 · 32 citations

Key Intermediate, Engineering, Streamlined Synthesis +16

Ketoreductase/Transaminase, One-Pot, Multikilogram Biocatalytic Cascade Reaction

Michael P. Burns, Wenying Bi, Hui Kim et al. · Organic Process Research & Development · 2021 · 25 citations

Biosynthesis, Ketone Reductase, Engineering +14