Aleš Šorf

Ribociclib shows potential for pharmacokinetic drug-drug interactions being a substrate of ABCB1 and potent inhibitor of ABCB1, ABCG2 and CYP450 isoforms in vitro

Aleš Šorf, Jakub Hofman, Radim Kučera et al. · Biochemical Pharmacology · 2018 · 52 citations

Cyp450 Isoforms, Biochemistry, Potent Inhibitor +8

Targeting Pharmacokinetic Drug Resistance in Acute Myeloid Leukemia Cells with CDK4/6 Inhibitors

Aleš Šorf, Simona Sucha, A Morell et al. · Cancers · 2020 · 41 citations · Full text

Brivanib Exhibits Potential for Pharmacokinetic Drug–Drug Interactions and the Modulation of Multidrug Resistance through the Inhibition of Human ABCG2 Drug Efflux Transporter and CYP450 Biotransformation Enzymes

Jakub Hofman, Aleš Šorf, Dimitrios Vagiannis et al. · Molecular Pharmaceutics · 2019 · 28 citations

In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley?

Ondřej Soukup, Jan Korábečný, David Maliňák et al. · Medicinal Chemistry · 2018 · 27 citations

Interactions of Alectinib with Human ATP-Binding Cassette Drug Efflux Transporters and Cytochrome P450 Biotransformation Enzymes: Effect on Pharmacokinetic Multidrug Resistance

Jakub Hofman, Aleš Šorf, Dimitrios Vagiannis et al. · Drug Metabolism and Disposition · 2019 · 22 citations · Full text