Paul Noordhuis

Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2.

Jan Hendrik Hooijberg, Henk J. Broxterman, Marcel Kool et al. · PubMed · 1999 · 445 citations

Medicine, Oncology, Pharmacology +17

5-Fluorouracil incorporation into RNA and DNA in relation to thymidylate synthase inhibition of human colorectal cancers

Paul Noordhuis, U. Holwerda, C.L. van der Wilt et al. · Annals of Oncology · 2004 · 261 citations · Full text

Medicine, Molecular Biology, Oncology +12

Circumvention of Methotrexate Resistance in Childhood Leukemia Subtypes by Rationally Designed Antifolates

Marianne G. Rots, Rob Pieters, Godefridus J. Peters et al. · Blood · 1999 · 214 citations

Medicine, Oncology, Pharmacology +14

Circumvention of Methotrexate Resistance in Childhood Leukemia Subtypes by Rationally Designed Antifolates

Marianne G. Rots, Rob Pieters, Godefridus J. Peters et al. · Blood · 1999 · 186 citations

Medicine, Oncology, Pharmacology +14

A Structurally Altered Human Reduced Folate Carrier with Increased Folic Acid Transport Mediates a Novel Mechanism of Antifolate Resistance

Gerrit Jansen, Robert Mauritz, Stavit Drori et al. · Journal of Biological Chemistry · 1998 · 163 citations · Full text

Medicine, Oncology, Pharmacology +15