5-Fluorouracil incorporation into RNA and DNA in relation to thymidylate synthase inhibition of human colorectal cancers

Paul Noordhuis, U. Holwerda, C.L. van der Wilt, +5

Annals of Oncology

Oncogenic AgentSynthase InhibitionMolecular BiologyColorectal CancerHuman Colorectal Cancers +4

Simultaneous analysis of plasma free fatty acids and their 3-hydroxy analogs in fatty acid β-oxidation disorders

Catarina G. Costa, L. Dorland, U. Holwerda, +4

Clinical Chemistry

Time dependence of the selective modulation of cisplatin-induced nephrotoxicity by WR2721 in the mouse.

M. Treskes, Epie Boven, U. Holwerda, +2

PubMed

Formulated Wr2721PharmacotherapyCisplatin DoseToxicological MechanismOxidative Stress +15

Pharmacokinetics of S-1, an oral formulation of ftorafur, oxonic acid and 5-chloro-2,4-dihydroxypyridine (molar ratio 1:0.4:1) in patients with solid tumors

Godefridus J. Peters, Paul Noordhuis, André B. P. Kuilenburg, +12

Cancer Chemotherapy and Pharmacology

Solid TumorsMedicinePharmacologyMolar Ratio 1:0.4:1Pharmacotherapy +7

Quantitative analysis of urinary acylglycines for the diagnosis of β-oxidation defects using GC-NCI-MS

C. G. Costa, W. S. Guérand, Edward A. Struys, +5

Journal of Pharmaceutical and Biomedical Analysis

Urinary AcylglycinesUrologyBiochemistryBioanalysisQuantitative Analysis +4

The chemical reactivity of the modulating agent WR2721 (ethiofos) and its main metabolites with the antitumor agents cisplatin and carboplatin

M. Treskes, U. Holwerda, Ina Klein, +2

Biochemical Pharmacology

Medicinal ChemistryBiochemistryModulating Agent Wr2721Natural SciencesMedicine +8

A pilot study to estimate incidence of guanidinoacetate methyltransferase deficiency in newborns by direct sequencing of the GAMT gene

Saadet Mercimek‐Mahmutoglu, Ana Pop, Warsha A. Kanhai, +6

Gene

Direct SequencingGenetic DisorderGeneticsInherited Metabolic DiseaseGenetic Epidemiology +9

The reversal of cisplatin-protein interactions by the modulating agent WR2721 and its metabolites WR1065 and WR33278

M. Treskes, U. Holwerda, Leo Nijtmans, +2

Cancer Chemotherapy and Pharmacology

ChromatinBiochemistryModulating Agent Wr2721Natural SciencesChromatin Remodeling +4

Quantification of 5-Fluorouracil Incorporation into RNA of Human and Murine Tumors as Measured with a Sensitive Gas Chromatography-Mass Spectrometry Assay

Godefridus J. Peters, Paul Noordhuis, Andrey B. Komissarov, +6

Analytical Biochemistry

OncologyOncogenic AgentMedicinePathology5-Fluorouracil Incorporation +5

The Effect of Food on the Pharmacokinetics of S-1 after Single Oral Administration to Patients with Solid Tumors

Godefridus J. Peters, Paul Noordhuis, Cornelis J. van Groeningen, +8

Clinical Cancer Research