Peter C. Tyler

One-Third-the-Sites Transition-State Inhibitors for Purine Nucleoside Phosphorylase

R.W. Miles, Peter C. Tyler, Richard H. Furneaux et al. · Biochemistry · 1998 · 245 citations

Life Sciences, Biochemistry, Molecular Biology +15

Transition State Structure of Purine Nucleoside Phosphorylase and Principles of Atomic Motion in Enzymatic Catalysis^,

Wuxian Shi, Greg A. Kicska, E.V. Fedorov et al. · Biochemistry · 2000 · 190 citations

Life Sciences, Biochemistry, Biology +17

Immucillin H, a powerful transition-state analog inhibitor of purine nucleoside phosphorylase, selectively inhibits human T lymphocytes

Greg A. Kicska, Long Li, Heidi Hörig et al. · Proceedings of the National Academy of Sciences · 2001 · 189 citations · Full text

Life Sciences, Immunology, Pharmacology +12

The 2.0 A structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with a transition-state analog inhibitor.

Vern L. Schramm, Steven C. Almo, Wuxian Shi et al. · Nature Structural Biology · 1999 · 157 citations

Life Sciences, Biochemistry, Molecular Biology +9

Femtomolar Transition State Analogue Inhibitors of 5′-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase from Escherichia coli

Vipender Singh, Gary B. Evans, Dirk H. Lenz et al. · Journal of Biological Chemistry · 2005 · 142 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15