Vern L. Schramm

The 2.0 A structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with a transition-state analog inhibitor.

Vern L. Schramm, Steven C. Almo, Wuxian Shi et al. · Nature Structural Biology · 1999 · 156 citations

Molecular Pharmacology, Cellular Enzymology, Biochemistry +10

Transition-state analysis of nucleoside hydrolase from Crithidia fasciculata

Benjamin A. Horenstein, David W. Parkin, B. Estupiñán et al. · Biochemistry · 1991 · 135 citations

Pre-steady-state transition-state analysis of the hydrolytic reaction catalyzed by purine nucleoside phosphorylase

Paul C. Kline, Vern L. Schramm · Biochemistry · 1995 · 96 citations

Engineering, Molecular Biology, Enzymatic Modification +17

Purine nucleoside phosphorylase. Inosine hydrolysis, tight binding of the hypoxanthine intermediate, and third-the-sites reactivity

Paul C. Kline, Vern L. Schramm · Biochemistry · 1992 · 85 citations

[13] Enzymatic transition-state analysis and transition-state analogs

Vern L. Schramm · Methods in enzymology on CD-ROM/Methods in enzymology · 1999 · 82 citations

Biochemistry, Enzyme Catalysis, Structure-function Enzyme Kinetics +2