Frédérik Fournier

Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition

Sergio Crespo‐Garcia, Pamela R. Tsuruda, Agnieszka Dejda et al. · Cell Metabolism · 2021 · 173 citations · Full text

Ocular Disease, Angiogenesis, Ophthalmology +10

Past history of obesity triggers persistent epigenetic changes in innate immunity and exacerbates neuroinflammation

Masayuki Hata, Elisabeth M. M. A. Andriessen, Maki Hata et al. · Science · 2023 · 155 citations

Innate Immune System, Immunology, Cell Death +22

Therapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results

Sergio Crespo‐Garcia, Frédérik Fournier, Roberto Diaz-Marin et al. · Nature Medicine · 2024 · 74 citations

Regenerative Medicine, Diabetic Retinopathy, Ocular Disease +10

Early-life peripheral infections reprogram retinal microglia and aggravate neovascular age-related macular degeneration in later life

Masayuki Hata, Maki Hata, Elisabeth M. M. A. Andriessen et al. · Journal of Clinical Investigation · 2023 · 27 citations · Full text

Ocular Disease, Pathological Neovascularization, Innate Immune System +19

Obesity triggers tumoral senescence and renders poorly immunogenic malignancies amenable to senolysis

Frédérik Fournier, Roberto Diaz-Marin, Frédérique Pilon et al. · Proceedings of the National Academy of Sciences · 2022 · 18 citations · Full text