Dan Heathcote

Discovery and Characterization of AZD6738, a Potent Inhibitor of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Kinase with Application as an Anticancer Agent

Kevin M. Foote, J. Willem M. Nissink, Thomas M. McGuire et al. · Journal of Medicinal Chemistry · 2018 · 331 citations · Full text

Medicine, Oncology, Pharmacology +16

Evaluation of a convenient method of assessing rodent visual function in safety pharmacology studies: Effects of sodium iodate on visual acuity and retinal morphology in albino and pigmented rats and mice

William S. Redfern, Sharon Storey, Karen Tse et al. · Journal of Pharmacological and Toxicological Methods · 2010 · 67 citations

Medicine, Ophthalmology, Pharmacology +13

Abstract 3343: The pre-clinical <i>in vitro</i> and <i>in vivo</i> activity of AZD6738: A potent and selective inhibitor of ATR kinase.

Sylvie M. Guichard, Elaine Brown, Rajesh Odedra et al. · Cancer Research · 2013 · 24 citations

Life Sciences, Molecular Biology, Oncology +17

Abstract 917: AZD2014, a dual mTORC1 and mTORC2 inhibitor is differentiated from allosteric inhibitors of mTORC1 in ER+ breast cancer

Sylvie M. Guichard, Zoë Howard, Dan Heathcote et al. · Cancer Research · 2012 · 17 citations

Medicine, Oncology, Pharmacology +13

Abstract 1823: AZ20, a novel potent and selective inhibitor of ATR kinase with in vivo antitumour activity

Xavier Jacq, Lisa M. Smith, Elaine Brown et al. · Cancer Research · 2012 · 13 citations

Life Sciences, Molecular Biology, Oncology +17