Y. Joy Yu Zuchero

Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys

Mihalis S. Kariolis, Robert C. Wells, Jennifer A. Getz et al. · Science Translational Medicine · 2020 · 355 citations

Pharmacy, Pharmaceutics, Pharmacology +17

Effector-attenuating Substitutions That Maintain Antibody Stability and Reduce Toxicity in Mice

Megan Lo, Hok Seon Kim, Raymond K. Tong et al. · Journal of Biological Chemistry · 2017 · 330 citations · Full text

Pharmacy, Immunology, Antibody Engineering +16

Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies

Y. Joy Yu Zuchero, Xiaocheng Chen, Nga Bien‐Ly et al. · Neuron · 2015 · 292 citations · Full text

Pharmacy, Neuroscience, Pharmacology +16

A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models

Bettina van Lengerich, Lihong Zhan, Dan Xia et al. · Nature Neuroscience · 2023 · 222 citations · Full text

Medicine, Neurobiology, Neuroscience +17

Targeting the transferrin receptor to transport antisense oligonucleotides across the mammalian blood-brain barrier

Scarlett J. Barker, Mai B. Thayer, Chaeyoung Kim et al. · Science Translational Medicine · 2024 · 119 citations

Pharmacy, Neuroscience, Pharmacology +17