Concepedia

Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies

Y. Joy Yu Zuchero, Xiaocheng Chen, Nga Bien‐Ly, Daniela Bumbaca, Raymond K. Tong, Xiaoying Gao, Shuo Zhang, Kwame Hoyte, Wilman Luk, Melanie A. Huntley,

Neuron · 2015 · 292 citations · 32 references

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32

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

Ye Zhang, Kenian Chen, Steven A. Sloan et al. · Journal of Neuroscience · 2014 · 5.4K citations · Full text

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β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

Robert Vassar, Brian D. Bennett, Safura Babu‐Khan et al. · Science · 1999 · 3.8K citations · Full text

, , +17

Transferrin receptor on endothelium of brain capillaries

Wilfred A. Jefferies, Malcolm R. Brandon, Simon V. Hunt et al. · Nature · 1984 · 1.1K citations

, , +13

Quantitative targeted absolute proteomics of human blood–brain barrier transporters and receptors

Yasuo Uchida, Sumio Ohtsuki, Yuki Katsukura et al. · Journal of Neurochemistry · 2011 · 909 citations

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Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target

Yichao Yu, Yin Zhang, Margaret Kenrick et al. · Science Translational Medicine · 2011 · 800 citations

, , +17