Concepedia
Statistics
Publications
29
Citations
2K
H-Index
24
Active since
1977
Affiliations
Roche (Switzerland)(Current)
Actelion (Switzerland)
Laboratoire de Chimie Organique
Morpho (United States)
Christian Hubschwerlen is an author at Roche (Switzerland) specializing in pharmacology, medicine, and natural sciences.
Top concepts
MedicinePharmacologyNatural SciencesDrug DiscoveryBiochemistryMedicinal ChemistryMicrobiologyDrug ResistanceAntimicrobial ResistanceChemical Biology
Publications per year
1977–2019
Refined crystal structure of β-lactamase from Citrobacter freundiiindicates a mechanism for β-lactam hydrolysis
Christian Oefner, A. D’Arcy, J. J. Daly et al. · Nature · 1990 · 298 citations
Crystal Structure, Biochemistry, Bacteriology +7
A Convenient Synthesis of L-(<i>S</i>)-Glyceraldehyde Acetonide from L-Ascorbic Acid
Christian Hubschwerlen · Synthesis · 1986 · 153 citations
Biosynthesis, Bioorganic Chemistry, Engineering +10
Peptide Deformylase as an Antibacterial Drug Target: Target Validation and Resistance Development
Christian Apfel, Hans H. Locher, Stefan Evers et al. · Antimicrobial Agents and Chemotherapy · 2001 · 126 citations · Full text
Bioorganic Chemistry, Peptide Engineering, Antibacterial Activity +19
Hydroxamic Acid Derivatives as Potent Peptide Deformylase Inhibitors and Antibacterial Agents
Christian Apfel, David W. Banner, Daniel Bur et al. · Journal of Medicinal Chemistry · 2000 · 111 citations · Full text
Antibacterial Agents, Antimicrobial Chemotherapy, Chemical Biology +19
An Enantioselective β‐Lactam Synthesis Starting from <scp>L</scp>‐<i>(S)</i>‐Glyceraldehyde Acetonide
Christian Hubschwerlen, Gerard M. Schmid · Helvetica Chimica Acta · 1983 · 97 citations
Enantioselective Synthesis, Derivatives, Remarkable Diastereoselectivity +12
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