Ronald J. Holewinski

Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease

Dong I. Lee, Guangshuo Zhu, Takashi Sasaki et al. · Nature · 2015 · 343 citations · Full text

Molecular Physiology, Disease Mechanism, Medicine +5

PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress

Mark J. Ranek, Kristen M. Kokkonen-Simon, Anna Chen et al. · Nature · 2019 · 129 citations · Full text

Cardiac Muscle, Cardiomyopathy, Molecular Physiology +8

Protein kinase A–dependent phosphorylation stimulates the transcriptional activity of hypoxia-inducible factor 1

John W. Bullen, Irina Tchernyshyov, Ronald J. Holewinski et al. · Science Signaling · 2016 · 113 citations · Full text

MYC assembles and stimulates topoisomerases 1 and 2 in a “topoisome”

Subhendu Das, Vladislav Kuzin, Donald P. Cameron et al. · Molecular Cell · 2021 · 106 citations · Full text

Chromatin, “ Topoisome ”, Myc Assembles +14

Cardiac resynchronization sensitizes the sarcomere to calcium by reactivating GSK-3β

Jonathan A. Kirk, Ronald J. Holewinski, Viola Kooij et al. · Journal of Clinical Investigation · 2013 · 84 citations · Full text

Cardiac Resynchronization, Cardiac Muscle, Heart Failure +22