Román Fischer

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Evanna L. Mills, Dylan G. Ryan, Hiran A. Prag et al. · Nature · 2018 · 1.7K citations · Full text

Inflammation, Reductive Stress, Anti-inflammatory +10

Colonic epithelial cell diversity in health and inflammatory bowel disease

Kaushal Parikh, Agne Antanaviciute, David Fawkner-Corbett et al. · Nature · 2019 · 820 citations

Inflammation, Autoimmune Disease, Immunology +8

Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling

Julie Adam, Emine Hatipoglu, Linda O′Flaherty et al. · Cancer Cell · 2011 · 567 citations · Full text

The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation

Alexander Hooftman, Stefano Angiari, Svenja Hester et al. · Cell Metabolism · 2020 · 542 citations · Full text

Inflammation, Anti-inflammatory, Signal Transduction +12

A late Middle Pleistocene Denisovan mandible from the Tibetan Plateau

Fahu Chen, Frido Welker, Chuan‐Chou Shen et al. · Nature · 2019 · 477 citations · Full text

Paleoanthropology, East Asian Languages, India-asia Collision +4