Román Fischer

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Evanna L. Mills, Dylan G. Ryan, Hiran A. Prag et al. · Nature · 2018 · 1.8K citations

Life Sciences, Biochemistry, Cell Biology +12

Colonic epithelial cell diversity in health and inflammatory bowel disease

Kaushal Parikh, Agne Antanaviciute, David Fawkner-Corbett et al. · Nature · 2019 · 879 citations

Life Sciences, Cell Biology, Immunology +14

The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation

Alexander Hooftman, Stefano Angiari, Svenja Hester et al. · Cell Metabolism · 2020 · 588 citations · Full text

Life Sciences, Cell Biology, Immunology +14

Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling

Julie Adam, Emine Hatipoglu, Linda O′Flaherty et al. · Cancer Cell · 2011 · 578 citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

A late Middle Pleistocene Denisovan mandible from the Tibetan Plateau

Fahu Chen, Frido Welker, Chuan‐Chou Shen et al. · Nature · 2019 · 496 citations · Full text

Dentistry, Anatomy, Paleontology +14