Loeckie De Zwart

Ibrutinib Dosing Strategies Based on Interaction Potential of CYP3A4 Perpetrators Using Physiologically Based Pharmacokinetic Modeling

Loeckie De Zwart, Jan Snoeys, Jan de Jong et al. · Clinical Pharmacology & Therapeutics · 2016 · 109 citations

The ontogeny of drug metabolizing enzymes and transporters in the rat

Loeckie De Zwart, Martijn Scholten, Johan Monbaliu et al. · Reproductive Toxicology · 2008 · 86 citations

Pharmacological Study, Biochemistry, Medicine +8

Stable isotope‐labelled intravenous microdose for absolute bioavailability and effect of grapefruit juice on ibrutinib in healthy adults

Ronald de Vries, Johan W. Smit, Peter Hellemans et al. · British Journal of Clinical Pharmacology · 2015 · 70 citations · Full text

A drug–drug interaction study of ibrutinib with moderate/strong CYP3A inhibitors in patients with B-cell malignancies

Jan de Jong, Peter Hellemans, Severijn De Wilde et al. · Leukemia & lymphoma/Leukemia and lymphoma · 2018 · 47 citations

IMI – oral biopharmaceutics tools project – evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds

Alison Margolskee, Adam S. Darwich, Xavier Pépin et al. · European Journal of Pharmaceutical Sciences · 2016 · 42 citations · Full text

Pharmacokinetic Modeling, Biochemistry, Medicine +8