Johan W. Smit

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

Alex Sparreboom, Judith van Asperen, Ulrich Mayer et al. · Proceedings of the National Academy of Sciences · 1997 · 877 citations · Full text

Active Epithelial Excretion, Gastrointestinal Pharmacology, Immunology +16

Phase I Dose-Escalation Study of JNJ-42756493, an Oral Pan–Fibroblast Growth Factor Receptor Inhibitor, in Patients With Advanced Solid Tumors

Josep Tabernero, Rastislav Bahleda, Rodrigo Dienstmann et al. · Journal of Clinical Oncology · 2015 · 371 citations

Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure

Johan W. Smit, Maarten T. Huisman, Olaf van Tellingen et al. · Journal of Clinical Investigation · 1999 · 355 citations · Full text

Genetics, Fetal Medicine, Gynecology +22

Substantial excretion of digoxin via the intestinal mucosa and prevention of long‐term digoxin accumulation in the brain by the mdrla P‐glycoprotein

Ulrich Mayer, Els Wagenaar, Jos H. Beijnen et al. · British Journal of Pharmacology · 1996 · 279 citations · Full text

Combination of ibrutinib with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) for treatment-naive patients with CD20-positive B-cell non-Hodgkin lymphoma: a non-randomised, phase 1b study

Anas Younes, Catherine Thiéblemont, Franck Morschhauser et al. · The Lancet Oncology · 2014 · 250 citations

Hematological Malignancy, Lymphoid Neoplasia, Medicine +6