AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism

Stephen L. Pinkosky, Jeffrey C. Hanselman, Cheryl D. Bradshaw, +9

Journal of Lipid Research

Intestinal Insulin Resistance and Aberrant Production of Apolipoprotein B48 Lipoproteins in an Animal Model of Insulin Resistance and Metabolic Dyslipidemia

Lisa Federico, Mark Naples, Denise Taylor, +1

Diabetes

NutritionPathologyApolipoprotein B48 LipoproteinsInsulin ReceptorInsulin Signaling +18

Intestinal Lipoprotein Overproduction, a Newly Recognized Component of Insulin Resistance, Is Ameliorated by the Insulin Sensitizer Rosiglitazone: Studies in the Fructose-Fed Syrian Golden Hamster

Gary F. Lewis, Kristine D. Uffelman, Mark Naples, +3

Endocrinology

Insulin Sensitizer RosiglitazoneNutritionInsulin SignalingOxidative StressMetabolic Syndrome +17

Metabolic effects of dietary cholesterol in an animal model of insulin resistance and hepatic steatosis

Heather Basciano, Abigale Miller, Mark Naples, +7

American Journal of Physiology-Endocrinology and Metabolism

NutritionFatty Liver DiseaseExperimental NutritionObesityMetabolic Syndrome +16

GLP-1 receptor agonism ameliorates hepatic VLDL overproduction and de novo lipogenesis in insulin resistance

Jennifer Taher, Christopher L. Baker, Carmelle Cuizon, +7

Molecular Metabolism

Hepatocyte-specific Deletion of Janus Kinase 2 (JAK2) Protects against Diet-induced Steatohepatitis and Glucose Intolerance

Sally Yu Shi, Rubén García-Martín, Robin E. Duncan, +15

Journal of Biological Chemistry

Hepatic mitochondrial and ER stress induced by defective PPARα signaling in the pathogenesis of hepatic steatosis

Qiaozhu Su, Chris Baker, Patricia Christian, +5

American Journal of Physiology-Endocrinology and Metabolism

Mitochondrial DysfunctionPathologyEr StressFatty Liver DiseaseOxidative Stress +20

C-reactive protein impairs hepatic insulin sensitivity and insulin signaling in rats: Role of mitogen-activated protein kinases

Xi Liang, Changting Xiao, Robert Bandsma, +3

Hepatology

Hepatic Lipase mRNA, Protein, and Plasma Enzyme Activity Is Increased in the Insulin-Resistant, Fructose-Fed Syrian Golden Hamster and Is Partially Normalized by the Insulin Sensitizer Rosiglitazone

Gary F. Lewis, Susan J. Murdoch, Kristine D. Uffelman, +5

Diabetes

Inhibition of sphingolipid synthesis improves dyslipidemia in the diet-induced hamster model of insulin resistance: Evidence for the role of sphingosine and sphinganine in hepatic VLDL-apoB100 overproduction

Mark J. Dekker, Chris Baker, Mark Naples, +5

Atherosclerosis

Insulin ResistanceMetabolic SyndromeInsulin SignalingBiochemistryMedicine +12