Gráinne M. O’Regan

Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

Alan D. Irvine, Ana Terron-Kwiatkowski, Yiwei Zhao et al. · Nature Genetics · 2006 · 2.9K citations

Major Predisposing Factor, Common Loss-of-function Variants, Atopic Dermatitis +8

Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris

Frances J.D. Smith, Alan D. Irvine, Ana Terron-Kwiatkowski et al. · Nature Genetics · 2006 · 1K citations

Biology, Mendelian Disorder, Genetic Disorder +10

Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema

Aileen Sandilands, Ana Terron-Kwiatkowski, Peter Hull et al. · Nature Genetics · 2007 · 660 citations

Allergy, Atopic Dermatitis, Genetic Disorder +11

Filaggrin in atopic dermatitis

Gráinne M. O’Regan, Aileen Sandilands, W.H. Irwin McLean et al. · Journal of Allergy and Clinical Immunology · 2008 · 343 citations

Autoimmune Disease, Atopic Dermatitis, Contact Dermatitis +2

Levels of filaggrin degradation products are influenced by both filaggrin genotype and atopic dermatitis severity

Sanja Kežić, Gráinne M. O’Regan, Nico L. H. Yau et al. · Allergy · 2011 · 288 citations · Full text