Gráinne M. O’Regan

Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

Alan D. Irvine, Ana Terron-Kwiatkowski, Yiwei Zhao et al. · Nature Genetics · 2006 · 3K citations

Medicine, Dermatology, Genetics +16

Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris

Frances J.D. Smith, Alan D. Irvine, Ana Terron-Kwiatkowski et al. · Nature Genetics · 2006 · 1K citations

Life Sciences, Genetics, Molecular Genetics +9

Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema

Aileen Sandilands, Ana Terron-Kwiatkowski, Peter Hull et al. · Nature Genetics · 2007 · 664 citations

Life Sciences, Genetics, Molecular Genetics +14

Filaggrin in atopic dermatitis

Gráinne M. O’Regan, Aileen Sandilands, W.H. Irwin McLean et al. · Journal of Allergy and Clinical Immunology · 2008 · 347 citations

Medicine, Dermatology, Immunology +12

Levels of filaggrin degradation products are influenced by both filaggrin genotype and atopic dermatitis severity

Gráinne M. O’Regan, Nico L. H. Yau, Aileen Sandilands et al. · Allergy · 2011 · 291 citations · Full text

Medicine, Dermatology, Molecular Genetics +16