Yan Yi Chen

High-yield genome engineering in primary cells using a hybrid ssDNA repair template and small-molecule cocktails

Brian R. Shy, Vivasvan S. Vykunta, Alvin Ha et al. · Nature Biotechnology · 2022 · 206 citations · Full text

Primary Cells, Genome Instability, High-yield Genome Engineering +11

RASA2 ablation in T cells boosts antigen sensitivity and long-term function

Julia Carnevale, Eric Shifrut, Nupura Kale et al. · Nature · 2022 · 201 citations · Full text

Base-editing mutagenesis maps alleles to tune human T cell functions

Ralf Schmidt, Carl C. Ward, Rama Dajani et al. · Nature · 2023 · 80 citations · Full text

Genetics, Genetic Engineering, Genetic Mechanism +6

Modular pooled discovery of synthetic knockin sequences to program durable cell therapies

Franziska Blaeschke, Yan Yi Chen, Ryan Apathy et al. · Cell · 2023 · 61 citations · Full text

Central control of dynamic gene circuits governs T cell rest and activation

Maya M. Arce, Jennifer M. Umhoefer, Nadia Arang et al. · Nature · 2024 · 21 citations · Full text