Joshua M. Dempster

Genetic and transcriptional evolution alters cancer cell line drug response

Uri Ben‐David, Benjamin A. Siranosian, Gavin Ha et al. · Nature · 2018 · 890 citations · Full text

Tumor Heterogeneity, Medicine, Oncogenic Agent +9

Extracting Biological Insights from the Project Achilles Genome-Scale CRISPR Screens in Cancer Cell Lines

Joshua M. Dempster, Jordan Rossen, Mariya Kazachkova et al. · 2019 · 423 citations · Full text

Project Achilles, Engineering, Genetic Dependencies +21

Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration

James M. McFarland, Zandra V. Ho, Guillaume Kugener et al. · Nature Communications · 2018 · 406 citations · Full text

Genetics, Large-scale Rnai Screens, Transcriptomics Technology +22

Chronos: a cell population dynamics model of CRISPR experiments that improves inference of gene fitness effects

Joshua M. Dempster, Isabella Boyle, Francisca Vázquez et al. · Genome biology · 2021 · 385 citations · Full text

Engineering, Genetics, Crispr Gene Knockout +19

Integrated cross-study datasets of genetic dependencies in cancer

Clare Pacini, Joshua M. Dempster, Isabella Boyle et al. · Nature Communications · 2021 · 317 citations · Full text