David I. Fisher

Structures of closed and open conformations of dimeric human ATM

Domagoj Baretić, Hannah Pollard, David I. Fisher et al. · Science Advances · 2017 · 128 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Discovery of AZD9833, a Potent and Orally Bioavailable Selective Estrogen Receptor Degrader and Antagonist

James S. Scott, Amber Balazs, Bernard Barlaam et al. · Journal of Medicinal Chemistry · 2020 · 111 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Nudix Hydrolases That Degrade Dinucleoside and Diphosphoinositol Polyphosphates Also Have 5-Phosphoribosyl 1-Pyrophosphate (PRPP) Pyrophosphatase Activity That Generates the Glycolytic Activator Ribose 1,5-Bisphosphate

David I. Fisher, Stephen T. Safrany, Peter Strike et al. · Journal of Biological Chemistry · 2002 · 80 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +12

The Next-Generation Oral Selective Estrogen Receptor Degrader Camizestrant (AZD9833) Suppresses ER+ Breast Cancer Growth and Overcomes Endocrine and CDK4/6 Inhibitor Resistance

Mandy Lawson, Natalie Cureton, Susana R�os et al. · Cancer Research · 2023 · 60 citations · Full text

Medicine, Oncology, Pharmacology +16

Systematic Evaluation of CRISPRa and CRISPRi Modalities Enables Development of a Multiplexed, Orthogonal Gene Activation and Repression System

Andrea Martella, Mike Firth, Ben Taylor et al. · ACS Synthetic Biology · 2019 · 55 citations

Life Sciences, Biotechnology, Genetics +15