Genome-wide pharmacogenetic investigation of a hepatic adverse event without clinical signs of immunopathology suggests an underlying immune pathogenesis

Andreas Kindmark, A Jawaid, Chris Harbron, +19

The Pharmacogenomics Journal

Genetic EpidemiologyImmunologyPathologyCirrhosisAutoimmune Liver Disease +15

In vivo CRISPR editing with no detectable genome-wide off-target mutations

Pınar Akçakaya, Maggie Bobbin, Jimmy A. Guo, +19

Nature

Vivo CrisprNatural SciencesGeneticsMolecular BiologyGenetic Engineering +6

Pre-clinical pharmacology of AZD3965, a selective inhibitor of MCT1: DLBCL, NHL and Burkitt’s lymphoma anti-tumor activity

Nicola J. Curtis, Lorraine Mooney, Lorna Hopcroft, +12

Oncotarget

Simultaneous inhibition of DNA-PK and Polϴ improves integration efficiency and precision of genome editing

Sandra Wimberger, Nina Akrap, Mike Firth, +25

Nature Communications

Engineered Cas9 extracellular vesicles as a novel gene editing tool

Xabier Osteikoetxea, Andreia Silva, Elisa Lázaro‐Ibáñez, +12

Journal of Extracellular Vesicles

BE-FLARE: a fluorescent reporter of base editing activity reveals editing characteristics of APOBEC3A and APOBEC3B

Matthew A. Coelho, Songyuan Li, Luna Simona Pane, +6

BMC Biology

CRISPR GUARD protects off-target sites from Cas9 nuclease activity using short guide RNAs

Matthew A. Coelho, Étienne De Braekeleer, Mike Firth, +4

Nature Communications

Systematic Evaluation of CRISPRa and CRISPRi Modalities Enables Development of a Multiplexed, Orthogonal Gene Activation and Repression System

Andrea Martella, Mike Firth, Ben Taylor, +5

ACS Synthetic Biology

EngineeringGeneticsSynthetic CircuitTranscriptional RegulationOrthogonal Gene Activation +17

Universal toxin-based selection for precise genome engineering in human cells

Songyuan Li, Nina Akrap, Silvia Cerboni, +19

Nature Communications

EngineeringMolecular BiologyUniversal Toxin-based SelectionDiphtheria ToxinGenome Engineering +14

Harnessing DSB repair to promote efficient homology-dependent and -independent prime editing

Martin Peterka, Nina Akrap, Songyuan Li, +11

Nature Communications