Shuichi Hiroyama

S-Nitrosylated Human Serum Albumin-mediated Cytoprotective Activity Is Enhanced by Fatty Acid Binding

Yu Ishima, Takaaki Akaike, Ulrich Kragh‐Hansen et al. · Journal of Biological Chemistry · 2008 · 49 citations · Full text

Life Sciences, Biochemistry, Pharmacology +9

Rational Design of Novel 1,3-Oxazine Based β-Secretase (BACE1) Inhibitors: Incorporation of a Double Bond To Reduce P-gp Efflux Leading to Robust Aβ Reduction in the Brain

Kouki Fuchino, Yasunori Mitsuoka, Moriyasu Masui et al. · Journal of Medicinal Chemistry · 2018 · 34 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Effects of endogenous ligands on the biological role of human serum albumin in S-nitrosylation

Yu Ishima, Takaaki Akaike, Ulrich Kragh‐Hansen et al. · Biochemical and Biophysical Research Communications · 2007 · 26 citations

Life Sciences, Biochemistry, Chemical Biology +12

One-step preparation of S-nitrosated human serum albumin with high biological activities

Yu Ishima, Shuichi Hiroyama, Ulrich Kragh‐Hansen et al. · Nitric Oxide · 2010 · 19 citations

Engineering, Biochemistry, Analytical Chemistry +3

The nociceptin/orphanin FQ receptor partial agonist sunobinop promotes non-REM sleep in rodents and patients with insomnia

Garth T. Whiteside, Donald J. Kyle, Ram P. Kapil et al. · Journal of Clinical Investigation · 2023 · 14 citations · Full text

Medicine, Neuroscience, Pharmacology +14