Concepedia

The nociceptin/orphanin FQ receptor partial agonist sunobinop promotes non-REM sleep in rodents and patients with insomnia

Garth T. Whiteside, Donald J. Kyle, Ram P. Kapil, Alessandra Cipriano, Ellie He, Mingyan Zhou, Manjunath S. Shet, Michele Hummel, Terri Knappenberger, Kazuya Fukumura,

Journal of Clinical Investigation · 2023 · 14 citations · 1 references

DOI Full text

Open access

Concepts

MedicineNeurosciencePharmacologyNeuropharmacologySleep MedicineInsomnia DisordersSleep BehaviorSleep PhysiologySleep-wake NeurobiologySleep-wake RegulationInsomnia PathophysiologyNon-rem Sleep Arousal DisordersPharmacologic Treatment Of InsomniaPharmacological Treatment Of InsomniaRem Sleep MechanismsSleepSleep-related Pain

Abstract

The potent and partial agonist sunobinop activates the nociceptin/orphanin-FQ peptide receptor and promotes non-REM sleep in rodents and patients with insomnia.

References

1

The National Center for Biotechnology Information

D. A. Benson, Mark S. Boguski, David J. Lipman et al. · Genomics · 1990 · 5.2K citations · Full text

Life Sciences, Biotechnology, Molecular Biology +10