Alessia Zotta

Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages

Marah C. Runtsch, Stefano Angiari, Alexander Hooftman et al. · Cell Metabolism · 2022 · 318 citations

Life Sciences, Cell Biology, Immunology +14

The metabolic function of pyruvate kinase M2 regulates reactive oxygen species production and microbial killing by neutrophils

Juliana E. Toller-Kawahisa, Carlos Hiroji Hiroki, Camila M. Silva et al. · Nature Communications · 2023 · 78 citations · Full text

Life Sciences, Immunology, Molecular Biology +17

Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon

Tristram A.J. Ryan, Alexander Hooftman, Aisling M. Rehill et al. · Nature Communications · 2023 · 64 citations · Full text

Life Sciences, Immunology, Infectious Diseases +17

Metabolic reprogramming of macrophages by PKM2 promotes IL-10 production via adenosine

Juliana E. Toller-Kawahisa, Paula Ramos Viacava, Eva M. Pålsson‐McDermott et al. · Cell Reports · 2025 · 42 citations · Full text

Life Sciences, Cell Biology, Immunology +17

KRIT1 Deficiency Promotes Aortic Endothelial Dysfunction

Francesco Vieceli Dalla Sega, Raffaella Mastrocola, Giorgio Aquila et al. · International Journal of Molecular Sciences · 2019 · 30 citations · Full text

Veterinary Medicine, Cell Biology, Pathobiology +17