Darby G. Brooke

RETRACTED: A New Class of Quinoline-Based DNA Hypomethylating Agents Reactivates Tumor Suppressor Genes by Blocking DNA Methyltransferase 1 Activity and Inducing Its Degradation

Jharna Datta, Kalpana Ghoshal, William A. Denny et al. · Cancer Research · 2009 · 264 citations · Full text

Medicine, Medicinal Chemistry, Oncology +13

Targeting the Warburg Effect in cancer; relationships for 2-arylpyridazinones as inhibitors of the key glycolytic enzyme 6-phosphofructo-2-kinase/2,6-bisphosphatase 3 (PFKFB3)

Darby G. Brooke, Ellen M. van Dam, Colin K. W. Watts et al. · Bioorganic & Medicinal Chemistry · 2014 · 43 citations · Full text

Medicine, Oncology, Pharmacology +14

Morpholylureas are a new class of potent and selective inhibitors of the type 5 17-β-hydroxysteroid dehydrogenase (AKR1C3)

Jack U. Flanagan, Graham J. Atwell, Daniel Heinrich et al. · Bioorganic & Medicinal Chemistry · 2014 · 37 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +8

3-(3,4-Dihydroisoquinolin-2(1<i>H</i>)-ylsulfonyl)benzoic Acids: Highly Potent and Selective Inhibitors of the Type 5 17-β-Hydroxysteroid Dehydrogenase AKR1C3

Stephen M. F. Jamieson, Darby G. Brooke, Daniel Heinrich et al. · Journal of Medicinal Chemistry · 2012 · 35 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

The Activity of SN33638, an Inhibitor of AKR1C3, on Testosterone and 17β-Estradiol Production and Function in Castration-Resistant Prostate Cancer and ER-Positive Breast Cancer

Yarong Diana Yin, Melissa Fu, Darby G. Brooke et al. · Frontiers in Oncology · 2014 · 31 citations · Full text

Medicine, Oncology, Pharmacology +16