Patrizia Sini

AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with <i>In vitro</i> and <i>In vivo</i> Antitumor Activity

Christine M. Chresta, Barry R. Davies, Ian Hickson et al. · Cancer Research · 2009 · 790 citations · Full text

Mtorc2 Substrate Akt, Cell Death, Pharmacotherapy +21

mTOR Inhibitor RAD001 (Everolimus) Has Antiangiogenic/Vascular Properties Distinct from a VEGFR Tyrosine Kinase Inhibitor

Heidi A. Lane, Jeanette M. Wood, Paul M.J. McSheehy et al. · Clinical Cancer Research · 2009 · 250 citations · Full text

An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin–polymerizing machine

Giorgio Scita, Pierluigi Tenca, Liliana B. Areces et al. · The Journal of Cell Biology · 2001 · 134 citations · Full text

Effector Region, Protein Assembly, Molecular Biology +18

Abl-dependent tyrosine phosphorylation of Sos-1 mediates growth-factor-induced Rac activation

Patrizia Sini, Angela Cannas, Anthony J. Koleske et al. · Nature Cell Biology · 2004 · 131 citations

Signal Transduction, Signaling Pathway, Receptor Tyrosine Kinase +6

Simultaneous inhibition of mTORC1 and mTORC2 by mTOR kinase inhibitor AZD8055 induces autophagy and cell death in cancer cells

Patrizia Sini, Dominic I. James, Christine M. Chresta et al. · Autophagy · 2010 · 87 citations · Full text

Mitophagy, Environmental Stress, Apoptosis +25