Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions

Toshimasa Yamauchi, Yasunori Nio, Toshiyuki Maki, +26

Nature Medicine

Metabolic SyndromeSystems BiologySignal TransductionBiochemistryMetabolic Actions +6

Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1

Masato Iwabu, Toshimasa Yamauchi, Miki Okada‐Iwabu, +23

Nature

Metabolic SyndromeSignal TransductionMolecular PhysiologyMitochondrial FunctionCell Signaling +12

A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity

Miki Okada‐Iwabu, Toshimasa Yamauchi, Masato Iwabu, +14

Nature

ObesityMetabolic SyndromeMolecular PharmacologyDiabetes ManagementSmall-molecule Adipor Agonist +11

A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B

Toshimasa Yamauchi, Kazuo Hara, Shiro Maeda, +42

Nature Genetics

Genome-wide Association StudyMetabolic SyndromeGenetic DeterminantDiabetes EpidemiologyGenetics +10

Insulin receptor substrate 2 plays a crucial role in β cells and the hypothalamus

Naoto Kubota, Yasuo Terauchi, Kazuyuki Tobe, +14

Journal of Clinical Investigation

Hypothalamic CircuitsInsulin SignalingGastrointestinal Peptide HormoneObesityMetabolic Syndrome +22

Crystal structures of the human adiponectin receptors

Hiroaki Tanabe, Yoshifumi Fujii, Miki Okada‐Iwabu, +21

Nature

Molecular PharmacologyCrystal StructureEngineeringBiochemistryG Protein-coupled Receptor +6

Global Mapping of Cell Type–Specific Open Chromatin by FAIRE-seq Reveals the Regulatory Role of the NFI Family in Adipocyte Differentiation

Hironori Waki, Masahiro Nakamura, Toshimasa Yamauchi, +15

PLoS Genetics

A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations

Minako Imamura, Shiro Maeda, Toshimasa Yamauchi, +28

Human Molecular Genetics

GeneticsGenetic EpidemiologyHuman PolymorphismGenome-wide Association StudiesClinical Genetics +20

Monocyte chemoattractant protein-1 (MCP-1) deficiency enhances alternatively activated M2 macrophages and ameliorates insulin resistance and fatty liver in lipoatrophic diabetic A-ZIP transgenic mice

Yasunori Nio, Toshimasa Yamauchi, Masato Iwabu, +5

Diabetologia

InflammationMetabolic SyndromeMonocyte Chemoattractant Protein-1DiabetesImmunology +9

Structural basis for compound C inhibition of the human AMP-activated protein kinase α2 subunit kinase domain

N. Handa, Tetsuo Takagi, Shinya Saijo, +11

Acta Crystallographica Section D Biological Crystallography

Molecular PharmacologyCrystal StructureSignal TransductionMolecular PhysiologyBiochemistry +13