Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation

Sylvain Latour, Romain Roncagalli, Riyan Chen, +5

Nature Cell Biology

Novel MechanismSignal TransductionSignaling PathwayReceptor Tyrosine KinaseImmune Regulation +6

Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor

Romain Roncagalli, James E R Taylor, Shaohua Zhang, +6

Nature Immunology

Host ResponseNatural Killer CellsSignal TransductionInnate Immune SystemImmunology +8

Quantitative Interactomics in Primary T Cells Provides a Rationale for Concomitant PD-1 and BTLA Coinhibitor Blockade in Cancer Immunotherapy

Javier Celis‐Gutierrez, Peter Blattmann, Yunhao Zhai, +9

Cell Reports

Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor–independent TCR signaling hub

Romain Roncagalli, Simon Hauri, Frédéric Di Fiore, +14

Nature Immunology

Surface Receptor Cd6Signal TransductionMedicineImmune RegulationImmunology +10

Molecular Dissection of 2B4 Signaling: Implications for Signal Transduction by SLAM-Related Receptors

Riyan Chen, Francis Relouzat, Romain Roncagalli, +4

Molecular and Cellular Biology

Molecular DissectionImmunologyNk CellsMolecular BiologyCell Death +18

Dual T cell– and B cell–intrinsic deficiency in humans with biallelic <i>RLTPR</i> mutations

Yi Wang, S. Cindy, Yun Ling, +32

The Journal of Experimental Medicine

The tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20) imposes a brake on antitumor activity of CD8 T cells

Marilyn Giordano, Romain Roncagalli, Pierre Bourdely, +8

Proceedings of the National Academy of Sciences

Loss of the LAT Adaptor Converts Antigen-Responsive T Cells into Pathogenic Effectors that Function Independently of the T Cell Receptor

Michaël Mingueneau, Romain Roncagalli, Claude Grégoire, +12

Immunity

Autoimmune DiseaseFunction IndependentlyAdaptive Immune SystemImmunologyAntigen Processing +10

Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics

Guillaume Voisinne, Kristof Kersse, Karima Chaoui, +15

Nature Immunology

Signal TransductionEngineeringMedicineT-regulatory CellCell Interaction +9

The proline-rich sequence of CD3ε controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes

Michaël Mingueneau, Amandine Sansoni, Claude Grégoire, +5

Nature Immunology

Preselection Cd4+cd8+ ThymocytesAutoimmune DiseaseProline-rich SequenceImmunologyAntigen Processing +7