Brian Diskin

PD-L1 engagement on T cells promotes self-tolerance and suppression of neighboring macrophages and effector T cells in cancer

Brian Diskin, Salma Adam, Marcelo Ferreira Cassini et al. · Nature Immunology · 2020 · 381 citations

Cancer Immunosurveillance, T Cells, Pd-l1 Engagement +10

SHP2 Inhibition Prevents Adaptive Resistance to MEK Inhibitors in Multiple Cancer Models

Carmine Fedele, Hao Ran, Brian Diskin et al. · Cancer Discovery · 2018 · 305 citations · Full text

RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer

Wei Wang, Jill M. Marinis, Allison M. Beal et al. · Cancer Cell · 2018 · 245 citations · Full text

Cancer Immunosurveillance, Pancreatic Cancer, Medicine +7

SHP2 inhibition diminishes KRASG12C cycling and promotes tumor microenvironment remodeling

Carmine Fedele, Shuai Li, Kai Wen Teng et al. · The Journal of Experimental Medicine · 2020 · 242 citations · Full text

Immunology, Cancer Biology, Tumor Biology +16

CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer

Hua Zhang, Camilla L. Christensen, Ruben Dries et al. · Cancer Cell · 2019 · 215 citations · Full text

Cancer Immunosurveillance, Medicine, Immunology +7