An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice

Shannon M. Reilly, Shian-Huey Chiang, Stuart J. Decker, +15

Nature Medicine

ObesityMetabolic SyndromeSignal TransductionMolecular PhysiologyObesity-related Metabolic Dysfunctions +10

TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue

Peng Zhao, Kai in Wong, Xiaoli Sun, +5

Cell

InflammationMetabolic SyndromeObesityEnergy HomeostasisSignal Transduction +12

Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1

Jonathan Mowers, Maeran Uhm, Shannon M. Reilly, +5

eLife

Nfκb PathwayImmunologyRenal InflammationCell DeathCatecholamine Resistance +21

A subcutaneous adipose tissue–liver signalling axis controls hepatic gluconeogenesis

Shannon M. Reilly, Maryam Ahmadian, Brian F. Zamarron, +14

Nature Communications

Otopetrin 1 Protects Mice From Obesity-Associated Metabolic Dysfunction Through Attenuating Adipose Tissue Inflammation

Guo-Xiao Wang, Kae Won Cho, Maeran Uhm, +8

Diabetes

ImmunologyAdipokinesInsulin SignalingOxidative StressObesity +20

A Rab10:RalA G protein cascade regulates insulin-stimulated glucose uptake in adipocytes

Tingting Xiong, Maeran Uhm, Dara E. Leto, +3

Molecular Biology of the Cell

Molecular PhysiologySignal TransductionBiochemistryNatural SciencesPhysiology +13

Phosphorylation of the exocyst protein Exo84 by TBK1 promotes insulin-stimulated GLUT4 trafficking

Maeran Uhm, Merlijn Bazuine, Peng Zhao, +4

Science Signaling

ImmunologyCellular PhysiologyInsulin SignalingInflammationMetabolic Syndrome +18

Negative Regulation of the RalGAP Complex by 14-3-3

Dara E. Leto, Maeran Uhm, A. H. Williams, +2

Journal of Biological Chemistry

Signal TransductionRalgap ComplexMolecular RegulationNatural SciencesMolecular Biology +4