Mark J. Gemkow

Eliapixant is a selective P2X3 receptor antagonist for the treatment of disorders associated with hypersensitive nerve fibers

Adam J. Davenport, Ioana Berindan‐Neagoe, Nico Bräuer et al. · Scientific Reports · 2021 · 62 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +17

An orally bioavailable positive allosteric modulator of the mGlu4 receptor with efficacy in an animal model of motor dysfunction

Stephen P. East, Samantha J. Bamford, Matthias G. A. Dietz et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 46 citations · Full text

Medicine, Neuroscience, Pharmacology +11

Exploiting differences in caspase-2 and -3 S2 subsites for selectivity: Structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitors

Michel Maillard, Frederick A. Brookfield, Stephen M. Courtney et al. · Bioorganic & Medicinal Chemistry · 2011 · 38 citations · Full text

Pharmacy, Chemical Biology, Medicinal Chemistry +14

Arylsulfonamide CB2 receptor agonists: SAR and optimization of CB2 selectivity

Monika Ermann, Doris Riether, Edward R. Walker et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 30 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

1,4-Diazepane compounds as potent and selective CB2 agonists: Optimization of metabolic stability

Doris Riether, Lifen Wu, Pier F. Cirillo et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 21 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15