Frederick A. Brookfield

Binding Mode and Structure–Activity Relationships around Direct Inhibitors of the Nrf2–Keap1 Complex

Eric Jnoff, Claudia Albrecht, John J. Barker et al. · ChemMedChem · 2014 · 168 citations

Phthalazinone Pyrazoles as Potent, Selective, and Orally Bioavailable Inhibitors of Aurora-A Kinase

Michael E. Prime, Stephen M. Courtney, Frederick A. Brookfield et al. · Journal of Medicinal Chemistry · 2010 · 85 citations · Full text

Chemoprevention Strategy, Pharmacotherapy, Aurora Kinase Inhibitors +18

Fragment Molecular Orbital Method Applied to Lead Optimization of Novel Interleukin-2 Inducible T-Cell Kinase (ITK) Inhibitors

Alexander Heifetz, Giancarlo Trani, Matteo Aldeghi et al. · Journal of Medicinal Chemistry · 2016 · 79 citations

Molecular Docking, Visual Inspection, Medicinal Chemistry +15

Discovery and Structure–Activity Relationship of Potent and Selective Covalent Inhibitors of Transglutaminase 2 for Huntington’s Disease

Michael E. Prime, Ole A. Andersen, John J. Barker et al. · Journal of Medicinal Chemistry · 2012 · 69 citations · Full text

Structure–activity Relationship, Biochemistry, G Protein-coupled Receptor +12

Development of a Series of Aryl Pyrimidine Kynurenine Monooxygenase Inhibitors as Potential Therapeutic Agents for the Treatment of Huntington’s Disease

Leticia Toledo‐Sherman, Michael E. Prime, Ladislav Mrzljak et al. · Journal of Medicinal Chemistry · 2015 · 61 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Neurodegenerative Diseases +15