Direna Alonso‐Curbelo

Senolytic CAR T cells reverse senescence-associated pathologies

Corina Amor, Judith Feucht, Josef Leibold et al. · Nature · 2020 · 968 citations · Full text

T-regulatory Cell, Immunology, Cellular Senescence +5

Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer

Marcus Ruscetti, John P. Morris, Riccardo Mezzadra et al. · Cell · 2020 · 392 citations · Full text

Pancreatic Cancer, Pancreas Cancer, Cellular Senescence +6

BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance

Nilgun Tasdemir, Ana Banito, Jae‐Seok Roe et al. · Cancer Discovery · 2016 · 385 citations · Full text

A gene–environment-induced epigenetic program initiates tumorigenesis

Direna Alonso‐Curbelo, Yu-Jui Ho, Cassandra Burdziak et al. · Nature · 2021 · 295 citations · Full text

Chromatin, Chromatin Structure, Medicine +9

Targeted Activation of Innate Immunity for Therapeutic Induction of Autophagy and Apoptosis in Melanoma Cells

Damiá Tormo, Agnieszka Chęcińska, Direna Alonso‐Curbelo et al. · Cancer Cell · 2009 · 176 citations · Full text

Therapeutic Induction, Cell Autophagy, Mitophagy +13