Geoff Del Rosario

Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers

Jennifer Cantley, Xiaofen Ye, Emma Rousseau et al. · Nature Communications · 2022 · 129 citations · Full text

Pharmacy, Molecular Biology, Oncology +14

The PI3K inhibitor GDC-0941 combines with existing clinical regimens for superior activity in multiple myeloma

Veerendra Munugalavadla, Sanjeev Mariathasan, Dionysos Slaga et al. · Oncogene · 2013 · 40 citations

Medicine, Oncology, Pharmacology +9

Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma

Xiaojing Wang, Wesley Blackaby, Vivienne Allen et al. · Journal of Medicinal Chemistry · 2019 · 36 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Systematic Variation of Pyrrolobenzodiazepine (PBD)-Dimer Payload Physicochemical Properties Impacts Efficacy and Tolerability of the Corresponding Antibody–Drug Conjugates

Leanna R. Staben, Jinhua Chen, Josefa dela Cruz-Chuh et al. · Journal of Medicinal Chemistry · 2020 · 19 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17